Unlike natural disasters, whose destruction is concentrated in a limited area over a period of days, and illnesses, which have devastating effects but are limited to individuals and their families, infectious disease has the terrifying power to disrupt everyday life on a global scale, overwhelming public and private resources and bringing trade and transportation to a grinding halt. In today’s world, it’s easier than ever to move people, animals, and materials around the planet, but the same advances that make modern infrastructure so efficient have made epidemics and even pandemics nearly inevitable. And as outbreaks of Ebola, MERS, yellow fever, and Zika have demonstrated, we are woefully underprepared to deal with the fallout. So what can — and must — we do in order to protect ourselves from mankind’s deadliest enemy? Drawing on the latest medical science, case studies, policy research, and hard-earned epidemiological lessons, Dr. Osterholm explores in detail the resources and programs we need to develop if we are to keep ourselves safer from infectious disease. As he has done in his recently published book, Deadliest Enemy: Our War Against Killer Germs, he shows us how we could wake up to a reality in which many antibiotics no longer cure, bioterror is a certainty, and the threat of a disastrous influenza pandemic looms ever larger. He also lays out a realistic “Crisis Agenda” for response that specifically addresses these challenges. Only by understanding the challenges we face can we prevent the unthinkable from becoming the inevitable.